Article
RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.
Molecular and cellular biology - 1 Jul 2009
Wang Xiaobo, Belguise Karine, O'Neill Christine F, Sánchez-Morgan Nuria, Romagnoli Mathilde, Eddy Sean F, Mineva Nora D, Yu Ziyang, Min Chengyin, Trinkaus-Randall Vickery, Chalbos Dany, Sonenshein Gail E
Abstract excerpt
Aberrant constitutive expression of NF-kappaB subunits, reported in more than 90% of breast cancers and multiple other malignancies, plays pivotal roles in tumorigenesis. Higher RelB subunit expression was demonstrated in estrogen receptor alpha (ERalpha)-negative breast cancers versus ERalpha-positive ones, due in part to repression of RelB synthesis by ERalpha signaling. Notably, RelB promoted a more invasive...
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