Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5

11 Oct 2012

Abstract excerpt

Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-κB, RelB/Bcl-2/Ras-driven pathway that promotes breast cancer cell migration. As the RelB/Blimp-1 pathway similarly required Ras signaling activation, we tested whether Blimp-1 plays a role in TGF-β1-mediated EMT. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Cancer Cells and Metastasis
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23054396
DOI: 10.1158/0008-5472.can-12-2270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5PMID 23054396Read ↗

RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.Semantic proximity Read ↗

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional RegulationSemantic proximity Read ↗

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transitionSemantic proximity Read ↗

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1Semantic proximity Read ↗

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.Semantic proximity Read ↗

TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell TransitionSemantic proximity Read ↗

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cellsSemantic proximity Read ↗

p53 and ΔNp63α Coregulate the Transcriptional and Cellular Response to TGFβ and BMP SignalsSemantic proximity Read ↗

Transforming growth factor-β 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transitionSemantic proximity Read ↗

PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomasSemantic proximity Read ↗

Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.Semantic proximity Read ↗

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasivenessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.