Article
Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2.
Nature cell biology - 1 Apr 2007
Wang Xiaobo, Belguise Karine, Kersual Nathalie, Kirsch Kathrin H, Mineva Nora D, Galtier Florence, Chalbos Dany, Sonenshein Gail E
Abstract excerpt
Aberrant constitutive expression of c-Rel, p65 and p50 NF-kappaB subunits has been reported in over 90% of breast cancers. Recently, we characterized a de novo RelB NF-kappaB subunit synthesis pathway, induced by the cytomegalovirus (CMV) IE1 protein, in which binding of p50-p65 NF-kappaB and c-Jun-Fra-2 AP-1 complexes to the RELB promoter work in synergy to potently activate transcription. Although RelB...
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