Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of population substructure on trend tests for genetic case-control association studies.

Biometrics - 1 Mar 2010

Zheng Gang, Li Zhaohai, Gail Mitchell H, Gastwirth Joseph L

Abstract excerpt

Hidden population substructure in case-control data has the potential to distort the performance of Cochran-Armitage trend tests (CATTs) for genetic associations. Three possible scenarios that may arise are investigated here: (i) heterogeneity of genotype frequencies across unidentified subpopulations (PSI), (ii) heterogeneity of genotype frequencies and disease risk across unidentified subpopulations (PSII), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Biometry
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Data Interpretation, Statistical

Share to Epidemiologic Methods

Share to Genetic Linkage

Share to Genetics, Population

Source

Identifiers

PMID: 19432788
DOI: 10.1111/j.1541-0420.2009.01264.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Impact of population substructure on trend tests for genetic case-control association studies.PMID 19432788Read ↗

The effects of SNP genotyping errors on the power of the Cochran-Armitage linear trend test for case/control association studies.Semantic proximity Read ↗

Issues in association analysis: error control in case-control association studies for disease gene discovery.Semantic proximity Read ↗

Robustness of case-control studies of genetic factors to population stratification: magnitude of bias and type I error.Semantic proximity Read ↗

The impact of diagnostic error on testing genetic association in case-control studies.Semantic proximity Read ↗

Robust genomic control and robust delta centralization tests for case-control association studies.Semantic proximity Read ↗

Robust trend tests for genetic association using matched case-control design.Semantic proximity Read ↗

On estimation of the variance in Cochran-Armitage trend tests for genetic association using case-control studies.Semantic proximity Read ↗

Cochran-Armitage test versus logistic regression in the analysis of genetic association studies.Semantic proximity Read ↗

On the robustness of tests of genetic associations incorporating gene-environment interaction when the environmental exposure is misspecified.Semantic proximity Read ↗

Relative efficiency of trend tests with misspecified genetic models in stratified analyses of case-control or cohort data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.