Article
Robustness of case-control studies of genetic factors to population stratification: magnitude of bias and type I error.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2004
Khlat Myriam, Cazes Marie-Hélène, Génin Emmanuelle, Guiguet Marguerite
Abstract excerpt
Case-control studies of genetic factors are prone to a special form of confounding called population stratification, whenever the existence of one or more subpopulations may lead to a false association, be it positive or negative. We quantify both the bias (in terms of confounding risk ratio) and the probability of false association (type I error) in the most unfavorable situation in which only one high-risk...
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