On the robustness of tests of genetic associations incorporating gene-environment interaction when the environmental exposure is misspecified.

Abstract excerpt

We consider the robustness of tests of genetic associations that incorporate gene-environment interactions when the environmental exposure is misspecified, which is likely the case when the exposure is continuous. We formally prove that, under the null hypothesis of no genetic association, misspecified ordinary logistic regression and profile likelihood (Chatterjee and Carroll, Biometrika. 2005;92:399-418)...

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