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Article

Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.

The Journal of clinical investigation - 1 Nov 2014

Klar Joakim, Hisatsune Chihiro, Baig Shahid M, Tariq Muhammad, Johansson Anna C V, Rasool Mahmood, Malik Naveed Altaf, Ameur Adam, Sugiura Kotomi, Feuk Lars, Mikoshiba Katsuhiko, Dahl Niklas

Abstract excerpt

There are 3 major sweat-producing glands present in skin; eccrine, apocrine, and apoeccrine glands. Due to the high rate of secretion, eccrine sweating is a vital regulator of body temperature in response to thermal stress in humans; therefore, an inability to sweat (anhidrosis) results in heat intolerance that may cause impaired consciousness and death. Here, we have reported 5 members of a consanguineous family...

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Identifiers

PMID: 25329695
DOI: 10.1172/JCI70720
PMCID: PMC4347256

Genes

ITPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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