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Article

Dominant role of Orai1 with STIM1 on the cytosolic entry and cytotoxicity of lead ions.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2009

Chiu Tai-Yu, Teng Hsiao-Chuan, Huang Ping-Chun, Kao Fu-Jen, Yang De-Ming

Abstract excerpt

Pb(2+) ions cause severe damages to living cells. In particular, our previous study showed that the Orai-STIM1 (stromal interacting protein 1)-formed store-operated Ca(2+) channels (SOCs) allow Pb(2+) entry. In relation to this, the present study investigates the molecular gating mechanism of Pb(2+) entry by Orai1 with STIM1, as well as the resulting cytotoxicity on human embryonic kidney HEK293 cells. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19429662
DOI: 10.1093/toxsci/kfp099

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dominant role of Orai1 with STIM1 on the cytosolic entry and cytotoxicity of lead ions.PMID 19429662Read ↗

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A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiencySemantic proximity Read ↗

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