Article

Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function

2025-01-26

Abstract excerpt

Calcium signaling is a fundamental molecular means of cellular regulation. Store operated calcium entry (SOCE) is a major intracellular signaling module, wherein calcium release from the endoplasmic reticulum triggers transmembrane STIM1 proteins to conformationally shift and oligomerize to prompt calcium influx from the extracellular environment. STIM1 senses ER calcium concentrations with its canonical EF-hand d...

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Literature Corpus work: 5033aecc-b1b7-5444-97ac-9307be30a464
DOI: 10.1101/2025.01.23.634525

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