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Article

Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2.

Journal of virology - 1 Sept 2000

Da Costa X, Kramer M F, Zhu J, Brockman M A, Knipe D M

Abstract excerpt

A number of studies have shown that replication-defective mutant strains of herpes simplex virus (HSV) can induce protective immunity in animal systems against wild-type HSV challenge. However, all of those studies used viruses with single mutations. Because multiple, stable mutations provide optimal levels of safety for live vaccines, we felt that additional mutations needed to be engineered into a candidate...

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Source

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Identifiers

PMID: 10933704
DOI: 10.1128/jvi.74.17.7963-7971.2000
PMCID: PMC112327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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