Article
Expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 subtype B pol and gagpol DNA vaccines.
Journal of virology - 1 Jun 2003
zur Megede Jan, Otten Gillis R, Doe Barbara, Liu Hong, Leung Louisa, Ulmer Jeffrey B, Donnelly John J, Barnett Susan W
Abstract excerpt
Control of the worldwide AIDS pandemic may require not only preventive but also therapeutic immunization strategies. To meet this challenge, the next generation of human immunodeficiency virus type 1 (HIV-1) vaccines must stimulate broad and durable cellular immune responses to multiple HIV antigens. Results of both natural history studies and virus challenge studies with macaques indicate that responses to both...
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