Article
Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens.
Vaccine - 6 Apr 2009
Feodorova V A, Pan'kina L N, Savostina E P, Kuznetsov O S, Konnov N P, Sayapina L V, Dentovskaya S V, Shaikhutdinova R Z, Ageev S A, Lindner B, Kondakova A N, Bystrova O V, Kocharova N A, Senchenkova S N, Holst O, Pier G B, Knirel Y A, Anisimov A P, Motin V L
Abstract excerpt
Deletion mutants in the lpxM gene in two Yersinia pestis strains, the live Russian vaccine strain EV NIIEG and a fully virulent strain, 231, synthesise a less toxic penta-acylated lipopolysaccharide (LPS). Analysis of these mutants revealed they possessed marked reductions in expression and immunoreactivity of numerous major proteins and carbohydrate antigens, including F1, Pla, Ymt, V antigen, LPS, and ECA....
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