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Article

Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles.

Biochimica et biophysica acta - 1 Oct 2009

Kim Sang-Hyun, Kim Keun-Su, Lee Sang-Rae, Kim Ekyune, Kim Myeong-Su, Lee Eun-Young, Gho Yong Song, Kim Jung-Woo, Bishop Russell E, Chang Kyu-Tae

Abstract excerpt

In an effort to devise a safer and more effective vaccine delivery system, outer membrane vesicles (OMVs) were engineered to have properties of intrinsically low endotoxicity sufficient for the delivery of foreign antigens. Our strategy involved mutational inactivation of the MsbB (LpxM) lipid A acyltransferase to generate OMVs of reduced endotoxicity from Escherichia coli (E. coli) O157:H7. The chromosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19695218
DOI: 10.1016/j.bbamem.2009.08.001
PMCID: PMC5007125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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