Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of native outer membrane vesicles from lpxL mutant strains of Neisseria meningitidis for use in parenteral vaccination.

Infection and immunity - 1 Jul 2005

Fisseha Makda, Chen Ping, Brandt Brenda, Kijek Todd, Moran Elizabeth, Zollinger Wendell

Abstract excerpt

Native outer membrane vesicles (NOMV) of Neisseria meningitidis consist of intact outer membrane and contain outer membrane proteins (OMP) and lipooligosaccharides (LOS) in their natural conformation and membrane environment. NOMV have been safely used intranasally in P1 studies with encouraging results, but they are too toxic for parenteral vaccination. We now report the preparation and characterization of lpxL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Antibodies, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacterial Outer Membrane Proteins

Share to Lipopolysaccharides

Share to Meningococcal Vaccines

Share to Rabbits

Share to Structure-Activity Relationship

Share to Vaccination

Source

Open in PubMed Open full text

Identifiers

PMID: 15972495
DOI: 10.1128/IAI.73.7.4070-4080.2005
PMCID: PMC1168616

Genes

OMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of native outer membrane vesicles from lpxL mutant strains of Neisseria meningitidis for use in parenteral vaccination.PMID 15972495Read ↗

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process.Semantic proximity Read ↗

Next-generation outer membrane vesicle vaccines against Neisseria meningitidis based on nontoxic LPS mutants.Semantic proximity Read ↗

Genetically Modified L3,7 and L2 Lipooligosaccharides from Neisseria meningitidis Serogroup B Confer a Broad Cross-Bactericidal ResponseSemantic proximity Read ↗

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.Semantic proximity Read ↗

Outer membrane vesicles as platform vaccine technologySemantic proximity Read ↗

Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: a comparison in mice.Semantic proximity Read ↗

Meningococcal Outer Membrane Vesicle Vaccines Derived from Mutant Strains Engineered To Express Factor H Binding Proteins from Antigenic Variant Groups 1 and 2Semantic proximity Read ↗

Novel approaches to Neisseria meningitidis vaccine designSemantic proximity Read ↗

Function of Neisserial Outer Membrane Phospholipase A in Autolysis and Assessment of Its Vaccine PotentialSemantic proximity Read ↗

Deletion of major porins from meningococcal outer membrane vesicle vaccines enhances reactivity against heterologous serogroup B Neisseria meningitidis strainsSemantic proximity Read ↗

Pre-clinical efficacy of a candidate Outer Membrane Vesicle gonococcal vaccine in comparison with 4CMenB.Semantic proximity Read ↗

Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.