Article
New insights on the structural/functional properties of recombinant human mannan-binding lectin and its variants.
Immunology letters - 27 Apr 2009
Rajagopalan Rema, Salvi Veena P, Jensenius Jens Chr, Rawal Nenoo
Abstract excerpt
Inefficient activation of complement lectin pathway in individuals with variant mannan-binding lectin (MBL) genotypes has been attributed to poor formation of higher order oligomers by MBL. But recent studies have shown the presence of large oligomers of MBL (approximately 450 kDa) in serum of individuals with variant MBL alleles. The recombinant forms of MBL (rMBL) variants except MBL/B that assemble into higher...
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