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Mitochondrial mutant cells are hypersensitive to ionizing radiation, phleomycin and mitomycin C.

Mutation research - 26 Apr 2009

Kulkarni Rohan, Reither Adrian, Thomas Robert A, Tucker James D

Abstract excerpt

Mitochondrial DNA (mtDNA) is an important contributor to the ATP-generating oxidative phosphorylation complex. Single nucleotide mutations in mitochondrial genes involved in ATP synthesis result in a broad range of diseases. Leber optic atrophy and Leigh's syndrome are two such diseases arising from point mutations in the mitochondrial genome. Here, ionizing radiation, phleomycin and mitomycin C (MMC) were used...

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Identifiers

PMID: 19428369
DOI: 10.1016/j.mrfmmm.2009.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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