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Article

Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts.

Radiation research - 1 Feb 2002

Boyle J M, Spreadborough A R, Greaves M J, Birch J M, Varley J M, Scott D

Abstract excerpt

Knockout mice with only one Trp53 allele (+/- genotype) are highly susceptible to radiation-induced cancers, possibly through numerical chromosome changes. Patients with the Li-Fraumeni syndrome, having heterozygous TP53 germline mutations (+/mut genotype), are also susceptible to spontaneous and radiogenic cancers. We have investigated the susceptibility of six Li-Fraumeni syndrome +/mut and six normal...

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Source

Identifiers

PMID: 11835679
DOI: 10.1667/0033-7587(2002)157[0158:dccigi]2.0.co;2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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