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Article

Cell response to oxidative stress induced apoptosis in patients with Leber's hereditary optic neuropathy

17 Nov 2004

Abstract excerpt

OBJECTIVES: Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease in which acute or subacute bilateral visual loss occurs preferentially in young men. Over 95% of LHON cases are associated with one of three mitochondrial DNA (mtDNA) point mutations, but only 50% of men and 10% of women who harbour a pathogenetic mtDNA mutation develop optic neuropathy. This incomplete penetrance and...

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PMID: 15548492
DOI: 10.1136/jnnp.2003.024372

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