Article
Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue.
Mitochondrion - 1 Sept 2009
Park Sang-Young, Shin Myung-Geun, Kim Hye-Ran, Oh Ji-Yeon, Kim Soo-Hyun, Shin Jong-Hee, Cho Yong-Bum, Suh Soon-Pal, Ryang Dong-Wook
Abstract excerpt
This study was designed to investigate the possibility that mtDNA mutations might arise in inflammatory or chronically damaged nasal polyp tissue from 23 patients. Thirteen patients (57%) displayed nasal polyp tissue-specific mtDNA mutations in the hypervariable segment of the control region and cytochrome b gene, which were not found in the corresponding blood cells and/or adjacent normal tissue. Nasal polyp...
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