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Article

Signal transduction and oxidative processes in sinonasal polyposis.

The Journal of allergy and clinical immunology - 1 Dec 2007

Cannady Steven B, Batra Pete S, Leahy Rachel, Citardi Martin J, Janocha Allison, Ricci Kristin, Comhair Suzy A A, Bodine Melanie, Wang Zeneng, Hazen Stanley L, Erzurum Serpil C

Abstract excerpt

BACKGROUND: Nasal polyposis is characterized by impaired regulation of nasal tissue growth and is associated with chronic inflammation, sinus infections, and low levels of nitric oxide (NO). Based on its critical role in mediating cell growth and antimicrobial function, decrease of NO levels has been implicated in the pathogenesis of nasal polyposis. OBJECTIVE: We sought to evaluate mechanisms for the low NO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17935768
DOI: 10.1016/j.jaci.2007.07.067

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