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Article

Identification of transmembrane domain 6 & 7 residues that contribute to the binding pocket of the urotensin II receptor.

Biochemical pharmacology - 15 Apr 2009

Holleran Brian J, Domazet Ivana, Beaulieu Marie-Eve, Yan Li Ping, Guillemette Gaétan, Lavigne Pierre, Escher Emanuel, Leduc Richard

Abstract excerpt

Urotensin II (U-II), a cyclic undecapeptide, is the natural ligand of the urotensin II (UT) receptor, a G protein-coupled receptor. In the present study, we used the substituted-cysteine accessibility method to identify specific residues in transmembrane domains (TMDs) six and seven of the rat urotensin II receptor (rUT) that contribute to the formation of the binding pocket of the receptor. Each residue in the...

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PMID: 19426676
DOI: 10.1016/j.bcp.2009.01.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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