Article

<i>PgaR</i> is a positive regulator of the <i>pgaABCD</i> biosynthetic operon in <i>Klebsiella pneumoniae</i>

2026-03-14

Abstract excerpt

The biosynthetic locus encoding the exopolysaccharide poly-N-acetyl-glucosamine (PNAG) is widely conserved across bacteria, including the WHO critical-priority pathogen Klebsiella pneumoniae (Kp). In Kp, PNAG synthesis is mediated by the pgaABCD operon, yet its lineage-specific regulation remains incompletely defined. Using a comparative genomics approach to interrogate the pgaABCD locus across the high-risk cl...

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Literature Corpus work: c61d9326-d418-5d2c-998b-b4bdbd98a946
DOI: 10.64898/2026.03.13.711557

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