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Article

DNA replication and transcription in mammalian mitochondria.

Annual review of biochemistry - 1 Jan 2007

Falkenberg Maria, Larsson Nils-Göran, Gustafsson Claes M

Abstract excerpt

The mitochondrion was originally a free-living prokaryotic organism, which explains the presence of a compact mammalian mitochondrial DNA (mtDNA) in contemporary mammalian cells. The genome encodes for key subunits of the electron transport chain and RNA components needed for mitochondrial translation. Nuclear genes encode the enzyme systems responsible for mtDNA replication and transcription. Several of the key...

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PMID: 17408359
DOI: 10.1146/annurev.biochem.76.060305.152028

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