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Article

eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development.

Oncology reports - 1 Jun 2009

Malta-Vacas Joana, Chauvin Celine, Gonçalves Lucilia, Nazaré Antonia, Carvalho Carlos, Monteiro Carolino, Bagrel Denyse, Jean-Jean Olivier, Brito Miguel

Abstract excerpt

It is now widely recognized that translation factors are involved in cancer development and that components of the translation machinery that are deregulated in cancer cells may become targets for cancer therapy. The eukaryotic Release Factor 3 (eRF3) is a GTPase that associates with eRF1 in a complex that mediates translation termination. eRF3a/GSPT1 first exon contains a (GGC)n expansion coding for proteins...

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Identifiers

PMID: 19424636
DOI: 10.3892/or_00000387

Genes

GSPT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development.PMID 19424636Read ↗

GGCn polymorphism of eRF3a/GSPT1 gene and breast cancer susceptibility.Semantic proximity Read ↗

Differential expression of GSPT1 GGCn alleles in cancer.Semantic proximity Read ↗

Studies on human eRF3-PABP interaction reveal the influence of eRF3a N-terminal glycin repeat on eRF3-PABP binding affinity and the lower affinity of eRF3a 12-GGC allele involved in cancer susceptibility.Semantic proximity Read ↗

C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction.Semantic proximity Read ↗

The Translation Termination Factor eRF3 Interacts Sequentially with eRF1 and ABCE1 on the RibosomeSemantic proximity Read ↗

Identification of translational release factor eRF1a binding sites on eRF3 in Euplotes octocarinatus.Semantic proximity Read ↗

Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer.Semantic proximity Read ↗

The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcomeSemantic proximity Read ↗

The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma.Semantic proximity Read ↗

Structural insights into eRF3 and stop codon recognition by eRF1.Semantic proximity Read ↗

N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination.Semantic proximity Read ↗

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.Semantic proximity Read ↗

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