Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.

PloS one - 1 Jan 2009

Piwko-Czuchra Aleksandra, Koegel Heidi, Meyer Hannelore, Bauer Martina, Werner Sabine, Brakebusch Cord, Fässler Reinhard

Abstract excerpt

BACKGROUND: There is a major discrepancy between the in vitro and in vivo results regarding the role of beta1 integrins in the maintenance of epidermal stem/progenitor cells. Studies of mice with skin-specific ablation of beta1 integrins suggested that epidermis can form and be maintained in their absence, while in vitro data have shown a fundamental role for these adhesion receptors in stem/progenitor cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Cells

Share to Epidermis

Share to Integrases

Share to Integrin beta1

Share to Keratin-5

Share to Keratinocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 19424505
DOI: 10.1371/journal.pone.0005488
PMCID: PMC2676508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.PMID 19424505Read ↗

Different Consequences of β1 Integrin Deletion in Neonatal and Adult Mouse Epidermis Reveal a Context-Dependent Role of Integrins in Regulating Proliferation, Differentiation, and Intercellular CommunicationSemantic proximity Read ↗

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.Semantic proximity Read ↗

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.Semantic proximity Read ↗

Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSPSemantic proximity Read ↗

Hemidesmosomes regulate epidermal differentiation during embryogenesisSemantic proximity Read ↗

The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin AppendagesSemantic proximity Read ↗

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermisSemantic proximity Read ↗

Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian EpidermisSemantic proximity Read ↗

Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing.Semantic proximity Read ↗

Wound Healing in the α2β1 Integrin-Deficient Mouse: Altered Keratinocyte Biology and Dysregulated Matrix Metalloproteinase ExpressionSemantic proximity Read ↗

Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.Semantic proximity Read ↗

Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.