Article
Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.
Journal of cell science - 15 Dec 2011
Rezvani Hamid Reza, Ali Nsrein, Serrano-Sanchez Martin, Dubus Pierre, Varon Christine, Ged Cécile, Pain Catherine, Cario-André Muriel, Seneschal Julien, Taïeb Alain, de Verneuil Hubert, Mazurier Frédéric
Abstract excerpt
In mouse and human skin, HIF-1α is constitutively expressed in the epidermis, mainly in the basal layer. HIF-1α has been shown to have crucial systemic functions: regulation of kidney erythropoietin production in mice with constitutive HIF-1α epidermal deletion, and hypervascularity following epidermal HIF-1α overexpression. However, its local role in keratinocyte physiology has not been clearly defined. To...
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