Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999

Zhu A J, Haase I, Watt F M

Abstract excerpt

Human epidermal stem cells express higher levels of beta1 integrins and are more adhesive than keratinocytes that are destined to differentiate. To investigate whether high beta1 integrin expression and adhesiveness are essential for maintaining keratinocytes in the stem cell compartment, we introduced a dominant-negative beta1 integrin mutant, CD8beta1, into cultured human keratinocytes, thereby interfering with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Epidermal Cells

Share to Epidermis

Share to Integrin beta1

Share to Keratinocytes

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 10359780
DOI: 10.1073/pnas.96.12.6728
PMCID: PMC21983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.PMID 10359780Read ↗

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.Semantic proximity Read ↗

Niche interactions in epidermal stem cellsSemantic proximity Read ↗

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescenceSemantic proximity Read ↗

Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotypeSemantic proximity Read ↗

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expressionSemantic proximity Read ↗

Location and phenotype of human adult keratinocyte stem cells of the skin.Semantic proximity Read ↗

Stem cell integrins: Implications for ex-vivo culture and cellular therapiesSemantic proximity Read ↗

Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro.Semantic proximity Read ↗

Delta regulates keratinocyte spreading and motility independently of differentiation.Semantic proximity Read ↗

Integrin signaling and mechanotransduction in regulation of somatic stem cellsSemantic proximity Read ↗

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysisSemantic proximity Read ↗

Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.