Article
Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study.
Pain - 1 Apr 2010
Hocking Lynne J, Smith Blair H, Jones Gareth T, Reid David M, Strachan David P, Macfarlane Gary J
Abstract excerpt
More than 1 in 10 adults in the general population experience chronic widespread body pain (CWP), which lies at one end of a continuous spectrum of pain ranging in both severity and duration. Neuroendocrine factors can modify the effect of known psychological and psychosocial risk factors for progression along the spectrum of pain and development of CWP, and genetic variants that affect neuroendocrine and neural...
Topics
- Adult
- Catechol O-Methyltransferase
- Chronic Disease
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Male
- Middle Aged
- Pain
- Polymorphism, Single Nucleotide