Article
Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist.
British journal of pharmacology - 1 Sept 2009
Sayers I, Hawley J, Stewart C E, Billington C K, Henry A, Leighton-Davies J R, Charlton S J, Hall I P
Abstract excerpt
BACKGROUND AND PURPOSE: Indacaterol is a novel beta(2)-adrenoceptor agonist in development for the treatment of chronic obstructive pulmonary disease. The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells. EXPERIMENTAL APPROACH:...
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