Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin.

Gastroenterology - 1 May 2009

Zhao Dan, Xu Dongkui, Zhang Xuemei, Wang Li, Tan Wen, Guo Yongli, Yu Dianke, Li Hui, Zhao Ping, Lin Dongxin

Abstract excerpt

BACKGROUND & AIMS: Overexpression of cyclooxygenase-2 (COX-2) is implicated in cancer development. This study examined the functional relevance of genetic polymorphisms in the COX-2 promoter and evaluated their associations with susceptibility to pancreatic cancer. METHODS: Genotypes and haplotypes of COX-2 -765G/C, -1195G/A, and -1290A/G were analyzed in 393 pancreatic cancer patients and 786 controls. Odds...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclooxygenase 2
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Genes, Reporter

Share to Luciferases

Share to Nucleophosmin

Share to Pancreatic Neoplasms

Share to Smoking

Source

Identifiers

PMID: 19422084
DOI: 10.1053/j.gastro.2009.01.071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin.PMID 19422084Read ↗

[Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer].Semantic proximity Read ↗

Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis.Semantic proximity Read ↗

Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk.Semantic proximity Read ↗

Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.Semantic proximity Read ↗

Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis.Semantic proximity Read ↗

Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancerSemantic proximity Read ↗

Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis.Semantic proximity Read ↗

Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L.Semantic proximity Read ↗

Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3.Semantic proximity Read ↗

Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population.Semantic proximity Read ↗

Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians.Semantic proximity Read ↗

Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.