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Article

Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population.

PloS one - 1 Jan 2011

Zhang Xue-Mei, Zhong Rong, Liu Li, Wang Ying, Yuan Ju-Xiang, Wang Peng, Sun Chuang, Zhang Zhi, Song Wen-Guang, Miao Xiao-Ping

Abstract excerpt

BACKGROUND: Over-expression and increased activity of cyclooxygenase (COX)-2 induced by smoking has been implicated in the development of cancer. This study aimed to explore the interaction between smoking and functional polymorphisms of COX-2 in modulation of gastric cardia adenocarcinoma (GCA) risk. METHODS AND FINDINGS: Three COX-2 polymorphisms, including -1195G>A (rs689466), -765G>C (rs20417), and 587Gly>Arg...

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Source

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Identifiers

PMID: 21779349
DOI: 10.1371/journal.pone.0021894
PMCID: PMC3136492

Genes

GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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