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Article

Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression

6 May 2009

Abstract excerpt

Recent studies in human fibroblasts have provided a new general paradigm of tumor suppression according to which oncogenic signaling produces DNA damage and this, in turn, results in ATM/p53-dependent cellular senescence. Here, we have tested this model in a variety of murine experimental systems. Overexpression of oncogenic Ras in murine fibroblasts efficiently induced senescence but this occurred in the absence...

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PMID: 19421407
DOI: 10.1371/journal.pone.0005475

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