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Article

Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation

3 Feb 2010

Abstract excerpt

p53, apoptosis, and senescence are frequently activated in preneoplastic lesions and are barriers to progression to malignancy. These barriers have been suggested to result from an ATM-mediated DNA damage response (DDR), which may follow oncogene-induced hyperproliferation and ensuing DNA replication stress. To elucidate the currently untested role of DDR in breast cancer initiation, we examined the effect of...

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PMID: 20133707
DOI: 10.1073/pnas.0910665107

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