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Article

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

Genes & development - 1 Jan 2007

Mallette Frédérick A, Gaumont-Leclerc Marie-France, Ferbeyre Gerardo

Abstract excerpt

Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking down ATM was also effective to bypass E2F1-induced senescence and in combination with Rb inactivation, inhibited RasV12-induced senescence. Cells that senesced in response to ca-STAT5A or RasV12 accumulated DNA damage...

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Identifiers

PMID: 17210786
DOI: 10.1101/gad.1487307
PMCID: PMC1759898

Genes

ATM
ATR

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