Article
PI3K/Akt pathway mutations in retinoblastoma.
Investigative ophthalmology & visual science - 1 Nov 2009
Cohen Yoram, Merhavi-Shoham Efrat, Avraham-Lubin Bat Chen R, Savetsky Michael, Frenkel Shahar, Pe'er Jacob, Goldenberg-Cohen Nitza
Abstract excerpt
PURPOSE: Many malignancies are known to be associated with abnormal activation of the PI3K-AKT pathway. Recently, a somatic mutation in the AKT1 gene (E17K) was identified in a small proportion of human tumors. This mutation activated AKT1 by means of abnormal membrane recruitment and stimulated downstream signaling. This study was designed to analyze AKT1 mutations in retinoblastoma and gain insights into the...
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