Article
PI3K/Akt pathway mutations in retinoblastoma.
Investigative ophthalmology & visual science - 1 Nov 2009
Cohen Yoram, Merhavi-Shoham Efrat, Avraham-Lubin Bat Chen R, Savetsky Michael, Frenkel Shahar, Pe'er Jacob, Goldenberg-Cohen Nitza
Abstract excerpt
PURPOSE: Many malignancies are known to be associated with abnormal activation of the PI3K-AKT pathway. Recently, a somatic mutation in the AKT1 gene (E17K) was identified in a small proportion of human tumors. This mutation activated AKT1 by means of abnormal membrane recruitment and stimulated...
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