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Article

Genetic variations of gpx-4 and male infertility in humans.

Biology of reproduction - 1 Apr 2003

Maiorino Matilde, Bosello Valentina, Ursini Fulvio, Foresta Carlo, Garolla Andrea, Scapin Margherita, Sztajer Helena, Flohe Leopold

Abstract excerpt

Phospholipid hydroperoxide glutathione peroxidase (PHGPx), the product of gpx-4, is the major selenoprotein in sperm and is considered essential for fertilization because of its multiple roles in spermatogenesis, such as hydroperoxide detoxification, formation of the mitochondrial capsule, and chromatin condensation. Genomic DNA sequences of 3.148 kilobases covering the whole gpx-4 and its flanking regions were...

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Identifiers

PMID: 12606444
DOI: 10.1095/biolreprod.102.007500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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