Article
Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity.
The Journal of pharmacology and experimental therapeutics - 1 Oct 2018
Heruth Daniel P, Shortt Katherine, Zhang Nini, Li Ding-You, Zhang Li Q, Qing Ye Shui
Abstract excerpt
Acetaminophen is commonly used to reduce pain and fever. Unfortunately, overdose of acetaminophen is a leading cause of acute liver injury and failure in many developed countries. The majority of acetaminophen is safely metabolized in the liver and excreted in the urine; however, a small percentage is converted to the highly reactive N-acetyl-p-benzoquinone imine (NAPQI). At therapeutic doses, NAPQI is...
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