Article
High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections.
Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009
Nishimura Yoshiaki, Sadjadpour Reza, Mattapallil Joseph J, Igarashi Tatsuhiko, Lee Wendy, Buckler-White Alicia, Roederer Mario, Chun Tae-Wook, Martin Malcolm A
Abstract excerpt
We and others have reported that the vast majority of virus-producing CD4(+) T cells during the acute infection of rhesus macaques with simian immunodeficiency virus (SIV) or CXCR4 (X4)-using simian/human immunodeficiency viruses (SHIVs) exhibited a nonactivated phenotype. These findings have been extended to show that resting CD4(+) T lymphocytes collected from SIV- or X4-SHIV-infected animals during the first...
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