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Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques

21 Sept 2016

Abstract excerpt

OBJECTIVE: Resting CD4 T cells have been recognized as the major cell reservoir of latent HIV-1 during antiretroviral therapy (ART). Using an simian immunodeficiency virus (SIV)/macaque model for AIDS and HIV-related neurocognitive disorders we assessed the contribution of the brain to viral latency and reactivation. DESIGN: Pigtailed macaques were dual inoculated with SIVDeltaB670 and SIV17E-Fr and treated with...

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PMID: 27898590
DOI: 10.1097/qad.0000000000001267

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