Article
CD8+ and CD20+ lymphocytes cooperate to control acute simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys: modulation by major histocompatibility complex genotype.
Journal of virology - 1 Dec 2005
Mao Hanwen, Lafont Bernard A P, Igarashi Tatsuhiko, Nishimura Yoshiaki, Brown Charlie, Hirsch Vanessa, Buckler-White Alicia, Sadjadpour Reza, Martin Malcolm A
Abstract excerpt
We have previously described two isogenic molecularly cloned simian immunodeficiency virus/human immunodeficiency virus chimeric viruses (SHIVs) that differ from one another by 9 amino acids and direct distinct clinical outcomes in inoculated rhesus monkeys. SHIV(DH12R-Clone 7), like other highly pathogenic CXCR4-tropic SHIVs, induces rapid and complete depletions of CD4+ T lymphocytes and immunodeficiency in...
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