Article
Evolutionary descent of a human chromosome 6 neocentromere: a jump back to 17 million years ago.
Genome research - 1 May 2009
Capozzi Oronzo, Purgato Stefania, D'Addabbo Pietro, Archidiacono Nicoletta, Battaglia Paola, Baroncini Anna, Capucci Antonella, Stanyon Roscoe, Della Valle Giuliano, Rocchi Mariano
Abstract excerpt
Molecular cytogenetics provides a visual, pictorial record of the tree of life, and in this respect the fusion origin of human chromosome 2 is a well-known paradigmatic example. Here we report on a variant chromosome 6 in which the centromere jumped to 6p22.1. ChIP-chip experiments with antibodies against the centromeric proteins CENP-A and CENP-C exactly defined the neocentromere as lying at chr6:26,407-26,491...
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