Article
A common stromal cell-derived factor-1 chemokine gene variant is associated with the early onset of type 1 diabetes.
Diabetes - 1 May 2001
Dubois-Laforgue D, Hendel H, Caillat-Zucman S, Zagury J F, Winkler C, Boitard C, Timsit J
Abstract excerpt
Type 1 diabetes results from the autoimmune destruction of pancreatic beta-cells. Although the disease shows a strong association with HLA class II alleles, other genes may influence the initiation or the rate of progression of the autoimmune process. The recruitment of mononuclear cells within the islets of Langerhans is a critical step in the pathogenesis of the disease. Because chemokines are cytokines that...
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