Article
Increased circulating levels of SDF-1 (CXCL12) in type 2 diabetic patients are correlated to disease state but are unrelated to polymorphism of the SDF-1β gene in the Iranian population.
Inflammation - 1 Jun 2012
Derakhshan Reza, Arababadi Mohammad Kazemi, Ahmadi Zahra, Karimabad Mojgan Noroozi, Salehabadi Vajihe Akbarpour, Abedinzadeh Mehdi, Khorramdelazad Hossein, Balaei Parisa, Kennedy Derek, Hassanshahi Gholamhossein
Abstract excerpt
Several environmental and genetic factors are believed to influence the onset of diabetes and its complications. It has also been established that cytokines play a key role in the pathogenesis of type 2 diabetes. Previous studies have revealed that the polymorphism at the stromal-derived factor 1β (SDF-1β) 3'A regulates the expression of SDF-1 (CXCL12). This study was aimed to explore this polymorphism in...
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