Article
Multilocus Bayesian meta-analysis of gene-disease associations.
American journal of human genetics - 1 May 2009
Newcombe Paul J, Verzilli Claudio, Casas Juan P, Hingorani Aroon D, Smeeth Liam, Whittaker John C
Abstract excerpt
Meta-analysis is a vital tool in genetic epidemiology. However, meta-analyses to identify gene-disease associations are compromised when contributing studies have typed partially overlapping sets of markers. Currently, only marginal analyses are possible, and these are restricted to the subset of studies typing that marker. This does not allow full use of available data and leads to the confounding of marker...
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