Article
In vitro homotypic and heterotypic interference by defective interfering particles of West Nile virus.
The Journal of general virology - 1 Nov 1991
Debnath N C, Tiernery R, Sil B K, Wills M R, Barrett A D
Abstract excerpt
Defective interfering (DI) particles of the flavivirus West Nile (WN) were generated after as few as two high multiplicity serial passages in Vero and LLC-MK2 cells. Six cell lines (Vero, LLC-MK2, L929, HeLa, BHK-21 and SW13) were used to assay interference by DI particles in a yield reduction assay. Interference was found to vary depending on the cell type used. The highest levels of interference were obtained...
Topics
- Animals
- Cell Line
- Defective Viruses
- HeLa Cells
- Hemagglutination
- Humans
- Microbiological Techniques
- Mutation
- Serial Passage
- Time Factors
- Vero Cells
- Viral Interference