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Potential High-Throughput Assay for Screening Inhibitors of West Nile Virus Replication

10 Nov 2003

Abstract excerpt

Prevention and treatment of infection by West Nile virus (WNV) and other flaviviruses are public health priorities. We describe a reporting cell line that can be used for high-throughput screening of inhibitors against all targets involved in WNV replication. Dual reporter genes, encoding Renilla luciferase (Rluc) and neomycin phosphotransferase (Neo), were engineered into a WNV subgenomic replicon, resulting in...

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PMID: 14610212
DOI: 10.1128/jvi.77.23.12901-12906.2003

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