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Article

Exclusion of West Nile Virus Superinfection through RNA Replication

3 Sept 2009

Abstract excerpt

Superinfection exclusion is the ability of an established viral infection to interfere with a second viral infection. Using West Nile virus (WNV) as a model, we show that replicating replicons in BHK-21 cells suppress subsequent WNV infection. The WNV replicon also suppresses superinfections of other flaviviruses but not nonflaviviruses. Mode-of-action analysis indicates that the exclusion of WNV superinfection...

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PMID: 19726510
DOI: 10.1128/jvi.01205-09

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