Article
Molecular biology of sodium channels and their role in cardiac arrhythmias.
The American journal of medicine - 1 Mar 2001
Grant A O
Abstract excerpt
The sodium channel is an integral membrane protein that plays a central role in conduction of the cardiac impulse in working cardiac myocytes and cells of the His-Purkinje system. The channel has two fundamental properties, ion conduction and gating. Specific domains of the channel protein control each of these functions. Ion conduction describes the mechanisms of the selective movement of sodium ion across the...
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