Article

A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

2022-03-05

Abstract excerpt

Resurgent currents ( I NaR ) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing, and contribute to neuronal hyperexcitability and disease pathophysiology. Here we show, for the first time, that I NaR can be reconstituted in a heterologous system by co-expression of sodium channel α-subunits and A-type fibroblast growth factor homologous factors (FHFs). Speci...

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Literature Corpus work: c5c570ba-21a7-56ca-bc72-2c6a8cc7d20d
DOI: 10.1101/2022.03.04.482974

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