Article
Evaluation of Chimerism Testing by Next-Generation Sequencing Using Insertion/Deletion Markers: Analytical Validation and Examples of Clinical Utilization.
The Journal of molecular diagnostics : JMD - 1 Jul 2026
Dutterer Shannon, Moore Christle, Giddens Maya, Smith Juliet, Williams Jenifer, Magwood Jessica, Silva Jeane, Murphey Cathi, Bravo-Egana Valia
Abstract excerpt
Post-transplant engraftment monitoring is essential to assess the risk of complications after allogeneic hematopoietic transplantation, such as graft failure and disease relapse. It is based on the analysis of the percentage of chimerism detected in the recipient. Chimerism analysis has been routinely performed using short tandem repeats (STRs). Next-generation sequencing (NGS) has made possible the use of other...
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